姓 名：阮浩
河南信阳人，博士，重庆大学生命科学学院副教授。从事生物物理与化学生物学研究，长期致力于与肿瘤相关的天然无序蛋白质结构动态与功能调控研究。近年来，以第一作者（含共同）在Nature Communications，PNAS，Chemical Science，Annu Rev Phys Chem等高水平SCI期刊发表学术论文。
教育背景
2010—2014 兰州大学，本科
2014—2019 北京大学，博士
工作经历
2019—2020 北京大学，研究助理
2020—2026 德国美因茨大学，博士后
2026.04至今 重庆大学，副教授
研究领域
在生物物理学以及化学生物学交叉领域，综合利用单分子荧光共振能量转移(smFRET)、小角X射线散射(SAXS)、荧光寿命成像(FLIM)以及遗传密码子拓展(GCE)等技术，研究天然无序蛋白质结构及功能调控，重点解析肿瘤相关转录因子及其相分离行为对放疗效果的影响机制。
科研项目
重庆大学科研启动经费 2026—2029。
代表性论文
1. Ruan H#, Dillenburg R#, Hosseini E, Girard M, Wittmann S, Lemke E. Differential conformational expansion of Nup98-HOXA9 oncoprotein from nanosized assemblies to macrophases. Nat Commun. 2025, 16(1): 10117.
2. Ruan H, Lemke E. Resolving conformational plasticity in mammalian cells with high-resolution fluorescence tools. Annu Rev Phys Chem. 2025, 76(1):103.
3. Yu M#, Gruzinov A#, Ruan H#, Scheidt T#, Chowdhury A, Giofrѐ S, Mohammed A, Caria J, Sauter P., Svergun D., Lemke E. A genetically encoded anomalous SAXS ruler to probe the dimensions of intrinsically disordered proteins. Proc Natl Acad Sci USA. 2024, 121(50) (co-first author).
4. Scheidt T#, Ruan H#, Yu M#, Lemke E.A. Stressing the role of a short linear motif in ataxin-2 condensation. Mol Cell. 2023, 83(12):1961 (co-first author).
5. Ruan H, Yu C, Niu X, Zhang W, Liu H, Chen L, Xiong R, Sun Q, Jin C, Liu Y, Lai L. Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway. Chem Sci. 2021, 12, 3004.
6. Ruan H, Kiselar J, Zhang W, Li S, Xiong R, Liu Y, Yang S, Lai L. Integrative structural modeling of a multidomain polo-like kinase. Phys Chem Chem Phys. 2020, 22, 27581.
7. Ruan H#, Sun Q#, Zhang W, Liu Y, Lai L. Targeting intrinsically disordered proteins at the edge of chaos. Drug Discov Today. 2019, 24(1): 217-227.
8. Yu M, Heidari M, Mikhaleva S, Tan P, Mingu S, Ruan H, Reinkemeier C, Obarska-Kosinska A, Siggel M, Beck M, Hummer G, Lemke E. Visualizing the disordered nuclear transport machinery in situ. Nature. 2023, 617(7959):162.
9. Ge Z, Bergonci T, Zhao Y, Zou Y, Du S, Liu M, Luo X, Ruan H, Garcia-Valencia L, Zhong S, Hou S, Huang Q, Lai L, Moura D S, Gu H, Dong J, Wu H, Dresselhaus T, Xiao J, Cheung A, Qu L. Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling. Science. 2017, 358(6370): 1596.
