师资队伍

姓 名：金凯

教授，博士生导师，重庆市研究生导师团队——杀虫真菌农药研发团队负责人。主要从事杀虫真菌农药的基础及应用研究。在基础研究方面，主要开展杀虫真菌侵染致病、产孢调控分子机制研究，特别是细胞壁组成和结构变化影响真菌侵染致病的作用机制以及杀虫真菌产孢方式转换的调控机制。在真菌农药的应用研究方面，针对茶叶、蔬菜、烟草上的重要病虫害，研发以杀虫真菌农药为核心的病虫害绿色防控的新技术，并进行应用示范。先后主持国家自然科学基金项目4项、其他省部级科研项目近10项。主研国家重点研发计划项目、国家“863”、国家公益行业专项等国家项目3项。以第一或通讯作者先后在PLoS Pathogens、PLoS Genetics、International Journal of Biological Macromolecules、Pest Management Science等国际知名刊物发表研究论文30余篇。获得国家授权发明专利3项。

• 2001.9-2008.6，西南大学生物技术中心，获农学博士学位；
  

• 1997.9-2001.7，西南农业大学植物保护学院，获农学学士学位。

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• 2015.9-至今，重庆大学生命科学学院，教授；

• 2015.10-2016.9，英国阿伯丁大学，访问学者；

• 2012.7-2015.8，重庆大学生命科学学院，副教授；

• 2010.10-2012.6，重庆大学生物工程学院，副教授；

• 2008.7-2010.9，重庆大学生物工程学院，讲师。

分子微生物学、昆虫病理学、微生物分子育种。

• 2019年度重庆大学优秀硕士论文指导教师；

• 2018年度重庆大学优秀硕士论文指导教师；

• 2018年度重庆大学技术发明一等奖，排名第三；

• 2017年度重庆大学先进工作者；

• 2009年度重庆市优秀博士论文；

• 中国菌物学会终身会员；

• 重庆市植物保护学会理事；

• 重庆市遗传学会理事；

• 重庆微生物学会第十届农业与环境微生物学专业委员会委员；

• 科技部、国家自然科学基金委、重庆、广西、福建及河北等科技项目及科技奖励的通讯评审专家；

• Journal of Advanced Research、Applied and Environmental Microbiology、Biological Control、Journal of Invertebrate Pathology等多个杂志的审稿人。

重庆市科技特派员

[1] 2023.1-2024.12，微生物肥对位防控烟草病虫害技术研究及数字化应用，重庆市烟草公司科技项目（项目编号：B20231NY1306，140万）

[2] 2022.1-2025.12，锌指蛋白MaNCP1介导硝酸盐代谢途径调控蝗绿僵菌产孢方式转换的作用机制，国家自然科学基金面上项目（项目编号：32172479，59万）；

[3] 2022.8-2025.7，转录因子 MaGti1 调控绿僵菌产孢方式转换的分子机制，重庆市自然科学基金面上项目（项目编号：CSTB2022NSCQ-MSX1185，5万）；

[4] 2019.12-2021.12，转录因子MaStu1调控蝗绿僵菌微循环产孢的分子机制，重庆市留学人员创业创新支持计划（项目编号：cx2019035，8万）；

[5] 2015.1-2018.12，几丁质合成对绿僵菌侵染致病的作用机制，国家自然科学基金面上项目（项目编号：31471820，85万）；

[6] 2018.7-2021.6，转录因子MaSom1调控绿僵菌微循环产孢的分子机制，重庆市基础研究与前沿探索项目（项目编号：CSTC, 2018jcyjAX0554，10万）；

[7] 2017.1-2018.12，O-甘露糖基转移酶MaPmt4影响绿僵菌毒力的机制，中央高校基本科研业务费专项资金项目——前沿交叉学科培育专项（项目编号：106112017CDJQJ298831，25万）；

[8] 2015.8-2018.7，绿僵菌中MaPacC的功能研究及其下游基因鉴定，重庆市自然基金面上项目（项目编号：CSTC, 2015jcyjA80037，5万）。

[1] Li MF, Wang SQ, Kang LH, Xu F, Lan X, He M, Jin K*, Xia YX*. Arginine metabolism governs microcycle conidiation by changing nitric oxide content in Metarhizium acridum. Applied Microbiology and Biotechnology. 2023, 107(4):1257–1268.

[2] Li CC, Xu DX, Hu MW, Zhang QP, Xia YX*, Jin K*. MaNCP1, a C2H2 Zinc Finger Protein, Governs the Conidiation Pattern Shift through Regulating the Reductive Pathway for Nitric Oxide Synthesis in the Filamentous Fungus Metarhizium acridum. Microbiology Spectrum. 2022, 10(3): e0053822.

[3] Wen ZQ, Xia YX*, Jin K*. MaSln1, a conserved histidine protein kinase, contributes to conidiation pattern shift independent of the MAPK pathway in Metarhizium acridum. Microbiology Spectrum. 2022, 10(2): e0205121.

[4] Li CC, Xia YX*, Jin K*. The C2H2 Zinc Finger Protein MaNCP1 Contributes to Conidiation through Governing the Nitrate Assimilation Pathway in the Entomopathogenic Fungus Metarhizium acridum. Journal of Fungi. 2022, 8(9): 942.

[5] Li CC, Xia YX*, Jin K*. N-terminal zinc fingers of MaNCP1 contribute to growth, stress tolerance, and virulence in Metarhizium acridum. International Journal of Biological Macromolecules. 2022, 216: 426–436.

[6] Wen ZQ, Fan Y, Xia YX*, Jin K*. MaOpy2, a Transmembrane Protein, Is Involved in Stress Tolerances and Pathogenicity and Negatively Regulates Conidial Yield by Shifting the Conidiation Pattern in Metarhizium acridum. Journal of Fungi. 2022, 8(6): 587.

[7] Song L, Xue XN, Wang SQ, Li J, Jin K*, Xia YX*. MaAts, an Alkylsulfatase, Contributes to Fungal Tolerances against UV-B Irradiation and Heat-Shock in Metarhizium acridum. Journal of Fungi. 2022, 8(3): 270.

[8] Du YR, Xia YX*, Jin K*. Enhancing the biocontrol potential of the entomopathogenic fungus in multiple respects via the overexpression of a transcription factor gene MaSom1. Journal of Fungi. 2022, 8(2): 105.

[9] Li CC, Zhang QP, Xia YX*, Jin K*. MaNmrA, a negative transcription regulator in nitrogen catabolite repression pathway, contributes to nutrient utilization, stress resistance, and virulence in entomopathogenic fungus Metarhizium acridum. biology-basel. 2021, 10(11): 1167.

[10] Li CC, Zhang QP, Xia YX*, Jin K*. MaAreB, a GATA transcription factor, is involved in nitrogen source utilization, stress tolerances and virulence in Metarhizium acridum. Journal of Fungi. 2021, 7(7): 512.

[11] Wen ZQ, Tian HT, Xia YX, Jin K*. O-mannosyltransferase MaPmt2 contributes to stress tolerance, cell wall integrity and virulence in Metarhizium acridum. Journal of Invertebrate Pathology. 2021, 84: 107649.

[12] Wen ZQ, Tian HT, Xia YX*, Jin K*. MaPmt1, a protein O-mannosyltransferase, contributes to virulence through governing the appressorium turgor pressure in Metarhizium acridum. Fungal Genetics and Biology. 2020, 145: 103480.

[13] Zhao TT, Wen ZQ, Xia YX*, Jin K*. The transmembrane protein MaSho1 negatively regulates conidial yield by shifting the conidiation pattern in Metarhizium acridum. Applied Microbiology and Biotechnology. 2020, 104(9): 4005–4015.

[14] Zhang MG, Wei QL, Xia YX*, Jin K*. MaPacC, a pH-responsive transcription factor, negatively regulates thermotolerance and contributes to conidiation and virulence in Metarhizium acridum. Current Genetics. 2020, 66(2): 397–408.

[15] Zhang JJ, Jiang H, Du YR, Keyhani NO, Xia YX*, Jin K*. Members of chitin synthase family in Metarhizium acridum differentially affect fungal growth, stress tolerances, cell wall integrity and virulence. PLoS Pathogens. 2019, 15(8): e1007964.

[16] Zhao TT, Tian HT, Xia YX*, Jin K*. MaPmt4, a protein O-mannosyltransferase, contributes to cell wall integrity, stress tolerance and virulence in Metarhizium acridum. Current Genetics. 2019, 65(4): 1025–1040.

[17] Gao PP, Jin K*, Xia YX*. The phosphatase gene MaCdc14 negatively regulates UV-B tolerance by mediating the transcription of melanin synthesis-related genes and contributes to conidiation in Metarhizium acridum. Current Genetics. 2020, 66(1): 141–153.

[18] Gao PP, Li MC, Jin K*, Xia YX*. The homeobox gene MaH1 governs microcycle conidiation for increased conidial yield by mediating transcription of conidiation pattern shift-related genes in Metarhizium acridum. Applied Microbiology and Biotechnology. 2019, 103(5): 2251–2262.

[19] Zhang J, Wang ZL, Keyhani NO, Peng, GX, Jin K*, Xia YX*. The protein phosphatase gene MaPpt1 acts as a programmer of microcycle conidiation and a negative regulator of UV-B tolerance in Metarhizium acridum. Applied Microbiology and Biotechnology. 2019, 103(3): 1351–1362.

[20] Du YR, Jin K*, Xia YX*. Involvement of MaSom1, a downstream transcriptional factor of cAMP/PKA pathway, in conidial yield, stress tolerances and virulence in Metarhizium acridum. Applied Microbiology and Biotechnology. 2018, 102: 5611–5623.

本科生：《身边的微生物》、《酶工程》

研究生：《酶工程》、《遗传学研究前沿》、《微生物与环境保护》、《专业外语》

分子生物学与基因工程、微生物资源开发与利用、环境及农业微生物。

地址：重庆市沙坪坝区大学城南路55号，重庆大学虎溪校区