姓 名：黄川
黄川，重庆大学生命科学学院教授、PI，从事于RBP功能与调控的研究（1，染色质定位RBP在转录调控中的非经典功能；2，RBP对环状RNA分子命运的调控机制）。自2018年成立课题组以来，以通讯作者在Nucleic Acids Res、Nat Commun、Genes Dev、Sci China Life Sci、Cell Discov、Trends Cell Biol等学术期刊发表论文20余篇，获国家级青年人才、重庆青年拔尖人才等计划支持。
主要成果
(#corresponding author/通讯作者)
(1). Chen X, Huang C#. Chromatin-interacting RNA-binding proteins regulate transcription. Trends in Cell Biology 2023; 33:625-629.
(2). Song Z, Lin J, Su R, Ji Y, Jia R, Li S, Shan G, Huang C#. eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells. Nucleic Acids Research 2022; 50:11529–11549. (F1000prime Recommendation)
(3). Chen L, Wang Y, Lin J, Song Z, Wang Q, Zhao W, Wang Y, Xiu X, Deng Y, Li X, Li Q, Wang X, Li J, Liu X, Liu K, Zhou J, Li K, Liu Y, Liao S, Deng Q, Xu C, Sun Q, Wu S, Zhang K, Guan M, Zhou T, Sun F, Cai X, Huang C#, Shan G#. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs. Nature Communications 2022; 13:5769.
(4). Jia R, Lin J, You J, Li S, Shan G, Huang C#. The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes. Nucleic Acids Research 2022; 50:9175-9189.
(5). Chen X, Zhou M, Yant L, Huang C#. Circular RNA in disease: basic properties and biomedical relevance. Wiley Interdisciplinary Reviews-RNA 2022; 13:e1723.
(6). Chen L, Huang C#, Shan G#. Circular RNAs in physiology and non-immunological diseases. Trends in Biochemical Sciences 2022; 47:250-264.
(7). You J, Song Z, Lin J, Jia R, Xia F, Li Z, Huang C#. RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus. Cell Discovery 2021; 7:79.
(8). Jia R, Song Z, Lin J, Li Z, Shan G, Huang C#. Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Nucleic Acids Research 2021; 49:6296-6314. (Research Highlights in Current Opinion in Insect Science)
(9). Song Z, Jia R, Tang M, Xia F, Xu H, Li Z, Huang C#. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Science China-Life Sciences 2021; 64:784-794.
(10). Song Z, Lin J, Li Z, Huang C#. The nuclear functions of long noncoding RNAs come into focus. Noncoding RNA Research 2021; 6:70-79.
(11). Zhou M, Xiao MS, Li Z, Huang C#. New progresses of circular RNA biology: from nuclear export to degradation. RNA Biology 2021; 18:1365-1373.
(12). Jia R, Xiao M, Li Z, Shan G, Huang C#. Defining an evolutionarily conserved role of GW182 in circular RNA degradation. Cell Discovery 2019; 5:49.
(13). Li Z, Kearse GM, Huang C#. The nuclear export of circular RNAs is primarily defined by their length. RNA Biology 2019; 16:1-4.
(14). Huang C, Liang D, Tatomer DC, Wilusz JE. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes & Development 2018; 32:639-644. (F1000prime Recommendation; Selected for an Outlook in Genes & Development; Perspectives and Commentary in Science: The long and short of RNA export. Science Vol. 360, No. 6393)
(15). Huang C, Wang X, Liu X, Cao S, Shan G. RNAi pathway participates in chromosome segregation in mammalian cells. Cell Discovery 2015; 1:15029. (Featured Article in Cell Discovery)
(16). Chen L, Huang C, Wang X, Shan G. Circular RNAs in Eukaryotic Cells. Current Genomics 2015; 16:312-318.
(17). Huang C, Shan G. What happens at or after transcription: Insights into circRNA biogenesis and function. Transcription 2015; 6:61-64.
(18). Li Z*, Huang C*, Bao C*, Chen L, Lin M, Wang X, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nature Structural & Molecular Biology 2015; 22:256-64. (*co-first author; Research Highlights in Nature Reviews Molecular Cell Biology: Circular RNAs promote transcription, 2015, 16(4); Perspectives and Commentary in Science: Circular RNA transcriptional circuits, 2015, 347(6228):1327; Featured Article & Most Cited Paper in Nature Structural & Molecular Biology)
(19). Dai L, Huang C, Chen L, Shan G, Li ZY. Altered expression of microRNAs in the response to ER stress. Science Bulletin 2015; 60:202-209.
