姓 名：罗忠
重庆大学生命科学学院教授、副院长，获得国家自然科学基金委优秀青年基金项目、重庆市杰出青年基金项目和重庆市青年拔尖人才支持计划。一直从事肿瘤发生发展分子作用机制、抗肿瘤药物传输系统的设计与疗效评价、免疫工程化调控以及组织再生与修复的研究。以第一/通讯作者在Nat Commun（3篇）、Science Advances、Cell Rep（2篇）、Angew Chem和Adv Mater等国内外高水平SCI期刊发表100余篇论文(平均影响因子12)，他引8000余次，授权专利10余项，入选全球顶尖科学家（前2%）。担任中国细胞生物学学会理事、中国生物物理学会微量元素分会常务委员/副秘书长、重庆市细胞生物学学会副理事长等兼职；主持国自然优青/重大研究计划培育项目、科技部重点研发子课题等20余项国家省部级项目，部分研究成果获得重庆市自然科学奖一等奖（第三），教学成果获得重庆大学教学成果一等奖和二等奖等奖项。
教育背景
2002年-2006年 重庆邮电大学，获得“测控技术与仪器”学士学位（2006）；
2006年-2011年 重庆大学生物工程学院，获得“生物医学工程”博士学位（2011，硕博连读）。
工作经历
2012.07—2015.09 新加坡南洋理工大学 化学与生物化学系 Research Fellowship
2015.10—2021.09 重庆大学生命科学学院 特聘研究员（百人计划）、博导
2021.10至今 重庆大学生命科学学院 弘深优秀学者、教授、博导
研究领域及奖项
一直从事肿瘤发生发展作用机制、免疫调控、合成生物材料、药物递送和组织修复的研究。以第一/通讯作者在Nat Commun(3篇)、Science Advances、Cell Rep(2篇)、Angew Chem和Adv Mater等国内外高水平SCI期刊发表100余篇论文(平均影响因子12)，他引8000余次，授权专利10余项。主持国自然科学基金优秀青年基金/重大研究计划培育项目、科技部重点研发子课题等20余项国家/省部级项目，部分研究成果获得重庆市自然科学奖一等奖（第三），重庆大学教学成果奖一等奖和二等奖。
人才称号
国家自然科学基金委优秀青年基金项目、重庆市杰出青年基金项目和重庆市青年拔尖人才支持计划
学术兼职
中国细胞生物学会理事
中国生物物理学会微量元素分会常务委员/副秘书长
重庆市细胞生物学学会副理事长
科研项目
国家自然科学基金面上项目，重庆市自然科学基金面上项目, 中央高校前沿交叉项目, 重庆大学‘百人计划’项目等。
代表性论文
1. Xijiao Ren, Zhuo Cheng, Jinming He, Xuemei Yao, Yingqi Liu, Kaiyong Cai, Menghuan Li*, Yan Hu*, Zhong Luo*.Bispecific aptamer nanoassemblies inhibit glycolysis-driven immunosuppression in triple negative breast cancer for cooperative immune checkpoint inhibition therapy. Nature Communication 2023, 14:7021.
2. Rui Xue, Xijiao Ren, Shuang Wang, Xinyue Ge, Xuemei Yao, Liqi Li, Junxia Min, Menghuan Li*, Zhong Luo*, Fudi Wang*. Cascade-amplification of melanoma- targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies. Nature Communication 2023, in press.
3. Yingqi Liu, Xuemei Yao, Youbo Zhao, De Fang, Lei Shi, Li Yang, Guanbin Song, Kaiyong Cai, Liqi Li, Qin Deng, Menghuan Li*, Zhong Luo*. Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells. Cell Reports 2023, 42(10): 113213.
4. Hong Wen, Liqi Li, Xinyue Ge, Yang Fei, Yanan Li, Menghuan Li*, Weidong Xiao*, Zhong Luo*. Hydrogel-Based Artificial Mucosa Restores Local Immune and Microbial Homeostasis for Treating Ulcerative Colitis. Advanced Functional Materials 2023,33(22):2212566.
5. Xinyue Ge, Hong Wen, Yang Fei, Rui Xue, Zhuo Cheng, Yanan Li, Kaiyong Cai, Liqi Li*, Menghuan Li*, Zhong Luo*. Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment. Biomaterials 2023, 299:122184.
6. Zhuo Cheng, Yan Hu, Yingqi Liu, Xuan Wang, Rui Xue, Kaiyong Cai, Liqi Li*, Menghuan Li*, Zhong Luo*. Engineered In-Situ-Forming Biomimetic Hydrogel with Self-Regulated Immunostimulatory Capacity Promotes Postoperative Tumor Treatment. Fundamental Research 2023,doi.org/10.1016/j.fmre.2023.02.029.
7. Yingqi Liu, Yang Fei, Xuan Wang, Bingbing Yang, Menghuan Li*, Zhong Luo*. Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity. Molecular Therapy 2023, 31, 7:1938-1959.
8. Huocheng Yang, Xuemei Yao, Yingqi Liu, Xinkun Shen*, Menghuan Li*, and Zhong Luo*. Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape. ACS Nano 2023, 17, 16:15328-15353.
9. Maohua Chen, Menghuan Li, Xijiao Ren, Fei Zhou, Yanan Li, Lu Tan, Zhong Luo*, Kaiyong Cai*, and Yan Hu*. DNAzyme Nanoconstruct-Integrated Autonomously-Adaptive Coatings Enhance Titanium-Implant Osteointegration by Cooperative Angiogenesis and Vessel Remodeling. ACS Nano 2023, 17(16): 15942-15961.
10. Tingting He, Lu Wang, Shuangquan Gou, Lu Lu, Genhua Liu, Kui Wang, Yulu Yang, Qiaojian Duan, Wenbo Geng, Peng Zhao*, Zhong Luo*, and Kaiyong Cai*. Enhanced Immunogenic Cell Death and Antigen Presentation via Engineered Bifidobacterium bifidum to Boost Chemo-immunotherapy. ACS Nano 2023, 17, 11:9953-9971.
11. Fei Zhou, Menghuan Li, Maohua Chen, Maowen Chen, Xiaodong Chen, Zhong Luo*, Kaiyong Cai*, and Yan Hu*. Redox Homeostas is Strategy for Inflammatory Macrophage Reprogramming in Rheumatoid Arthritis Based on Ceria Oxide Nanozyme-Complexed Biopolymeric Micelles. ACS Nano 2023, 17, 5, 4358-4372.
12. Xingwei Ding, Wenyan Jiang, Menghuan Li, Shiyu Xiong, Wei Wei, Mingzhuo Liu, Hongbo Xin*, Zhong Luo*, Yanli Zhao*. An ROS/DAMP dual-scavenging nanomedicine for normalizing macrophage polarization and microbiome in colitis. Nano Today 2023, 51:101924.
13. Lu Tan, Menghuan Li, Hang Chen, Yuchen Zhang, Yuan Liu, Maohua Chen, Zhong Luo*, Kaiyong Cai*, Yan Hu*. Dynamic hydrogel with environment-adaptive autonomous wound-compressing ability enables rapid hemostasis and inflammation amelioration for hemorrhagic wound healin. Nano Today 2023, 52:101962.
14. Yuan Zhang, Zhuo Cheng, Zaiyang Liu, Xinkun Shen, Chunyuan Cai, Menghuan Li*, Zhong Luo*. Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration. Advanced Science 2023, 202303958.
15. Qiwen Guan#, Xuan Wang#, Danfeng Cao, Menghuan Li, Zhong Luo*, Xiaoyuan Mao*. Calcium phosphate-based nanoformulation selectively abolishes phenytoin resistance in epileptic neurons for ceasing seizures. Small 2023, 2300395.
16. Jiawu Yu, Yuchen Zhang, Liqi Li, Yang Xiang, Xuemei Yao, Youbo Zhao, Kaiyong Cai, Menghuan Li*, Zhongjun Li*, Zhong Luo*. Coordination-driven FBXW7 DNAzyme-Fe nanoassembly enables a binary switch of breast cancer cell cycle checkpoint responses for enhanced ferroptosis-radiotherapy. Acta Biomaterialia 2023, 169:434-450.
17. Zhuo Cheng, Chencheng Xue, Minghan Liu, Zhiming Cheng, Gan Tian, Menghuan Li, Rui Xue, Xuemei Yao, Yuan Zhang*, Zhong Luo*. Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment. Acta Biomaterialia 2023, 169:289-305.
18. Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen*, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo*, Yan Hu*. Bone-targeting cell membrane-engineered CaCO3-based nanoparticles restore local bone homeostasis for microenvironment-responsive osteoporosis treatment. Chemical Engineering Journal 2023, 470:144145.
19. Yingqi Liu, Yunyun Wu, Zhong Luo*, Menghuan Li*. Designing supramolecular self-assembly nanomaterials as stimuli-responsive drug delivery platforms for cancer therapy. iScience 2023, 26, 3: 106279.
20. Yuan Liu, Lu Tan, Yan Huang, Maohua Chen, Menghuan Li, Kaiyong Cai*, Zhong Luo*, Yan Hu*. Multifunctional antibiotics-free hydrogel dressings with self-regulated nitric oxide-releasing kinetics for improving open wound healing. J Mater Chem B 2023,11: 3650-3668.
21. Youbo Zhao, Menghuan Li, Zhong Luo*, Min Su*, Chao Yu*. Recent Progress in the Therapeutic Modulation of Lactate for Cancer Treatment. Advanced Therapeutics 2023,6(3) :2200254.
22. Xuan Wang#, Yingqi Liu#, Chen-Cheng Xue , Yan Hu , Yuanyuan Zhao, Kaiyong Cai, Menghuan Li*, Zhong Luo*. A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses. Nature Communication 2022, 13: 5685.
23. Yanan Li, Menghuan Li, Li Liu, Chencheng Xue, Yang Fei, Xuan Wang, Yuchen Zhang, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Cell-specific metabolic reprogramming of tumors for bioactivatable ferroptosis therapy. ACS Nano, 2022, 16(3):3965-3984.
24. Zhong Luo#, Xuemei Yao#, Menghuan Li#, De Fang, Yang Fei, Zhuo Cheng, Yingying Xu*, Bo Zhu*. Modulating tumor physical microenvironment for fueling CAR-T cell therapy. Advanced Drug Delivery Reviews, 2022, 185:114301.
25. Maowen Chen, Dong Wang, Menghuan Li, Ye He, Tingting He, Maohua Chen, Yan Hu*, Zhong Luo*, and Kaiyong Cai*. Nanocatalytic bio-functional MOF coating on titanium implants promotes osteoporotic bone regeneration through cooperative pro-osteoblastogenesis MSC reprogramming. ACS Nano 2022, 16, 9:15397–15412
26. Yujia Wei, Maohua Chen, Menghuan Li, Dong wang, Kaiyong Cai*, Zhong Luo*, Yan Hu*. Aptamer/Hydroxyapatite-Functionalized Titanium Substrate Promotes Implant Osseointegration Via Recruiting Mesenchymal Stem Cells. ACS Applied Materials & Interfaces 2022, 14, 38, 42915-42930.
27. Ke Li, Chuanchuan Lin, Menghuan Li, Kun Xu, Ye He, Yulan Mao, Lu Lu, Wenbo Geng, Xuemin Li, Zhong Luo*, Kaiyong Cai*. Multienzyme-like reactivity cooperatively impairs glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways in triple-negative breast cancer for sensitized ferroptosis therapy. ACS Nano, 2022, 16, 2, 2381-2398.
28. Chencheng Xue, Hui Zhang, Xuan Wang, Haoyu Du, Lu Lu, Yang Fei, Yanan Li, Yuchen Zhang, Menghuan Li*, Zhong Luo*. Bio-inspired engineered ferritin-albumin nanocomplexes for targeted ferroptosis therapy. Journal of Controlled Release 2022, 351:581-596.
29. Maohua Chen, Menghuan Li, Yujia Wei, Chencheng Xue, Maowen Chen, Yang Fei, Lu Tan, Zhong Luo*, Kaiyong Cai*, Yan Hu*. ROS-activatable biomimetic interface mediates in-situ bioenergetic remodeling of osteogenic cells for osteoporotic bone repair. Biomaterials 2022, 291:121878.
30. Bei-Bei Yan, Chen-Cheng Xue, Meng-HuanLi, Liang Dong, Yang Zhao, Zhong Luo*, Shu-Hong Yu*. All-in-one hollow nanoformulations enabled imaging-guided Mn-amplified chemophototherapy against hepatocellular carcinoma. Nano Today 2022, 43, 101382.
31. Maohua Chen, Yuting Sun, Yanhua Hou, Zhong Luo*, Menghuan Li, Yujia Wei, Maowen Chen, Lu Tan, Kaiyong Cai*, Yan Hu*. Constructions of ROS-responsive titanium-hydroxyapatite implant for mesenchymal stem cell recruitment in peri-implant space and bone formation in osteoporosis microenvironment. Bioactive Materials 2022, 18, 56-71.
32. Dong Wang, Mao-Wen Chen, YuJia Wei, WenBo Geng, Yan Hu,* Zhong Luo,* Kaiyong Cai*. Construction of Wogonin Nanoparticle-Containing Strontium-Doped Nanoporous Structure on Titanium Surface to Promote Osteoporosis Fracture Repair. Advanced Healthcare Materials 2022, 2201405.
33. Xiaoyuan Mao*, Xuan Wang , Mingzhu Jin , Qin Li, Jining Ji, Menghuan Li, Honghao Zhou, Zhaoqian Liu*, Weilin Jing*, Yanli Zhao*, Zhong Luo*. Critical involvement of lysyl oxidase in seizureinduced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications. Acta Pharmaceutica Sinica B 2022,12(9):3513-3528.
34. Lu Tan, Menghuan Li, Zhong Luo*, Kaiyong Cai*, Yan Hu*. Black phosphorus biomaterials for photo-controlled bone tissue engineering. Composites Part B: Engineering 2022, 246, 110245.
35. Yanhua Hou, Yang Fei, Zehong Liu, Yingqi Liu*, Menghuan Li*, Zhong Luo*. Black phosphorous nanomaterials as a new paradigm for postoperative tumor treatment regimens. Journal of Nanobiotechnology 2022 20:366.
36. Wenbo Geng, Maowen Chen, Bailong Tao, Rong Wang, Dong Wang, Ke Li, Chuanchuan Lin, Xuezhe Liu, Pengfei Gao, Zhong Luo*, Kaiyong Cai*. Cell-free DNA depletion via cell-penetrating poly(disulfide)s for rheumatoid arthritis therapy. Applied Materials Today 2022, 26, 101351.
37. Lu Tan, Yan Hu*, Menghuan Li ,Yuchen Zhang, Chencheng Xue, Maohua Chen, Zhong Luo*, Kaiyong Cai*. Remotely-activatable extracellular matrix-mimetic hydrogel promotes physiological bone mineralization for enhanced cranial defect healing. Chemical Engineering Journal 2022, 431(4):133382.
38. Maowen Chen, Yan Hu*, Yanhua Hou, Menghuan Li, Lu Tan, Maohua Chen, Wenbo Geng, Bailong Tao, Zhong Luo*, Kaiyong Cai*. Magnesium/gallium-layered nanosheets on titanium implants mediate osteogenic differentiation of MSCs and osseointegration under osteoporotic condition. Chemical Engineering Journal 2022, 427, 130982.
39. Xuemei Yao, Wei Li, Liqi Li*, Menghuan Li, Youbo Zhao, De Fang, Xiaohua Zeng*, Zhong Luo*. YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Cell Death & Disease 2022, 13(3):258.
40. Lei Shi#, Yingqi Liu#, Menghuan Li*, Zhong Luo*. Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS Journal 2022, 289(13):3655-3665
41. Chencheng Xue#, Menghuan Li#, Changhuang Liu#, Yanan Li, Yang Fei, Yan Hu, Kaiyong Cai, Yanli Zhao, Zhong Luo*. NIR-actuated remote activation of ferroptosis in target tumor cells through a photothermally responsive iron-chelated biopolymer nanoplatform. Angew Chem Int Ed 2021, 60, 8938-8947.
42. Chencheng Xue#, Menghuan Li#, Linawati Sutrisno, Beibei Yan, Yang Zhao, Yan Hu, Kaiyong Cai, Yanli Zhao, Shuhong Yu*, Zhong Luo*. Bioresorbable scaffolds with biocatalytic chemotherapy and in situ microenvironment modulation for postoperative tissue repair. Advanced Functional Materials 2021, 31:2008732.
43. Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wu, Menghuan Li,* and Zhong Luo*. Emerging roles of energy metabolism in ferroptosis regulation of tumor cells. Advanced Science 2021, 8, 2100997
44. Xuan Wang#, Youbo Zhao#, Lei Shi, Yan Hu, Guanbin Song, Kaiyong Cai, Menghuan Li*, Zhong Luo*. Tumor-targeted disruption of lactate transport with reactivity-reversible nanocatalysts to amplify oxidative damage. Small 2021,17(20): 2100130.
45. Ke Li, Kun Xu, Ye He, Lu Lu, Yulan Mao, Pengfei Gao, Genhua Liu, Jing Wu, Yuchen Zhang, Yang, Xiang, Zhong Luo*, Kaiyong Cai*. Functionalized tumor-targeting nanosheets exhibiting Fe(II) overloading and GSH consumption for ferroptosis activation in liver tumor. Small 2021, 17(40): 2102046.
46. Xuan Wang, Yuanyuan Zhao, Yan Hu, Yang Fei, Youbo Zhao, Chencheng Xue, Kaiyong Cai, Menghuan Li*, Zhong Luo*. Activatable biomineralized nanoplatform remodels the intracellular environment of multidrug-resistant tumors for enhanced ferroptosis/apoptosis therapy. Small 2021, 17(47): 2102269.
47. Chencheng Xue#, Linawati Sutrisno#, Menghuan Li#, Wei Zhu, Yang Fei, Changhuang Liu, Xuan Wang, Kaiyong Cai, Yan Hu*, Zhong Luo*. Implantable multifunctional black phosphorus nanoformulation-deposited biodegradable scaffold for combinational photothermal/ chemotherapy and wound healing. Biomaterials 2021, 269, 120623.
48. Hong Wen, Yang Fei, Ruisi Cai, Xuemei Yao, Yanan Li, Xuan Wang, Chencheng Xue, Yan Hu, Menghuan Li*, Zhong Luo*. Tumor-activatable biomineralized nanotherapeutics for integrative glucose starvation and sensitized metformin therapy. Biomaterials 2021, 278, 121165.
49. Yuchen Zhang, Liqi Li, Yanan Li, Yang Fei, Chencheng Xue, Xuemei Yao, Youbo Zhao, Xuan Wang, Menghuan Li*, Zhong Luo*. An ROS-Activatable Nanoassembly Remodulates Tumor Cell Metabolism for Enhanced Ferroptosis Therapy. Advanced Healthcare Materials 2021, 11(2): 2101702.
50. Lu Lu, Genhua Liu, Chuanchuan Lin, Ke Li, Tingting He, Jixi Zhang, Zhong Luo*, Kaiyong Cai*. Mitochondrial metabolism targeted nanoplatform for efficient triple-negative breast cancer combination therapy. Advanced Healthcare Materials 2021, 10(20):2100978.
51. Zhiwen Deng, Menghuan Li, Yan Hu*, Ye He, Bailong Tao, Zhang Yuan, Rong Wang, Maowen Chen, Zhong Luo*, Kaiyong Cai*. Injectable Biomimetic Hydrogels Encapsulating Gold/metal–organic frameworks Nanocomposites for Enhanced Antibacterial and Wound Healing Activity under Visible Light Actuation. Chemical Engineering Journal 2021, 420, 129668.
52. Maohua Chen, Yan Hu∗, Yanhua Hou, Yuting Sun, Maowen Chen, Menghuan Li, Lu Tan, Zhong Luo*, Kaiyong Cai*. Construction of a reactive oxygen species-responsive biomimetic multilayered titanium implant for in situ delivery of α-melanocyte-stimulating hormone to improve bone remolding in osteoporotic rats. Applied Materials Today 2021, 23, 101059.
53. Rui Zeng#, Tingting He#, Lu Lu, Ke Li, Zhong Luo*, Kaiyong Cai*. Ultra-thin metal-organic framework nanosheets for chemo-photodynamic synergistic therapy. Journal of Materials Chemistry B 2021, 9, 4143-4153.
54. Maowen Chen#, Bailong Tao#, Yan Hu*, Menghuan Li, Maohua Chen, Lu Tan, Zhong Luo*, Kaiyong Cai*. Enhanced biocompatibility and osteogenic differentiation of mesenchymal stem cells of titanium by Sr–Ga clavate double hydroxides. Journal of Materials Chemistry B 2021,9:6029-6036.
55. Li Liu, Liqi Li, Menghuan Li*, Zhong Luo*. Autophagy-dependent ferroptosis as a therapeutic target in cancer. ChemMedChem 2021, 16(19):2942-2950.
56. Chencheng Xue#, Menghuan Li#, Yang Zhao#, Jun Zhou, Yan Hu, Kaiyong Cai, Yanli Zhao, Shuhong Yu*, Zhong Luo*. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Science Advances 2020, 6: eaax1346.
57. Youbo Zhao#, Menghuan Li#, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo*. HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications. Cell Reports 2020, 33: 108487.
58. Xuan Wang#, Menghuan Li#, Yanhua Hou, Yanan Li, Xuemei Yao, Chencheng Xue, Yang Fei, Yang Xiang, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Tumor-microenvironment-activated in situ self-assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Advanced Functional Materials 2020, 30: 2000229.
59. Ke Li, Chuanchuan Lin, Ye He, Lu Lu, Kun Xu, Bailong Tao, Zengzilu Xia, Rui Zeng, Yulan Mao, Zhong Luo*, Kaiyong Cai*. Engineering of cascade-responsive nanoplatform to inhibit lactate efflux for enhanced tumor chemo-immunotherapy. ACS Nano 2020, 14: 14164-14180.
60. Lu Lu#, Xiaojing Zhao#, Tiwei Fu, Ke Li, Ye He, Zhong Luo*, Liangliang Dai, Rui Zeng, Kaiyong Cai*. An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy. Biomaterials 2020, 230: 119666.
61. Xuemei Yao#, Menghuan Li#, Bing Li#, Chencheng Xue, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Tumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapy. Chemical Engineering Journal 2020, 390: 124516.
62. Menghuan Li#, Hui Zhang#, Yanhua Hou, Xuan Wang, Chencheng Xue, Wei Li, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. State-of-the-art iron-based nanozymes for biocatalytic tumor therapy. Nanoscale Horizons 2020, 5: 202-217.
63. Yanan Li#, Linawati Sutrisno#, Yanhua Hou, Yang Fei, Chengcheng Xue, Yan Hu, Menghuan Li*, Zhong Luo*. A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy. Chemical Communications 2020, 56: 9978-9981.
64. Yang Fei#, Menghuan Li#, Yanan Li, Xuan Wang, Chencheng Xue, Zuosu Wu, Jiaying Xu,Zilu Xiazeng*, Kaiyong Cai*, Zhong Luo*. Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small- molecule anticancer drug co-delivery. Nanocsale 2020, 31: 2111224.
65. Ke Li, Lu Lu, Chencheng Xue, Ju Liu, Ye He, Jun Zhou, Zengzilu Xia, Liangliang Dai, Zhong Luo*, Yulan Mao*, Kaiyong Cai*. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale 2020, 12: 130-144.
66. Caiyun Mu, Ye He, Yan Hu*, Menghuan Li, Maowen Chen, Rong Wang, Yang Xiang, Zhong Luo*, Kaiyong Cai*. Construction of chemokine substance P-embedded biomimetic multilayer onto bioactive magnesium silicate-titanium implant for bone regeneration. Applied Materials Today 2020, 20: 100777.
67. Maowen Chen, Yan Hu*, Yanhua Hou, Menghuan Li, Maohua Chen, Lu Tana, Caiyun Mu, Bailong Tao, Zhong Luo*, Kaiyong Cai*. Osteogenesis regulation of mesenchymal stem cellsviaautophagy induced by silica-titanium composite surfaces with different mechanical moduli. Journal of Materials Chemistry B 2020, 8: 9314-9324.
68. Lu Tan, Yan Hu*, Yanhua Hou, Maowen Chen, Chencheng Xue, Maohua Chen, Yuting Sun, Caiyun Mu, Zhong Luo*, Kaiyong Cai*. Osteogenic differentiation of mesenchymal stem cells by silica/calcium micro-galvanic effects on the titanium surface. Journal of Materials Chemistry B 2020, 8: 2286-2295.
69. Lu Lu, Bing Li, Chuanchuan Lin, Ke Li, Genhua Liu, Zengzilu Xia, Zhong Luo*, Kaiyong Cai*. Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy. Journal of Materials Chemistry 2020, 8: 3918-3928.
70. Youbo Zhao#, Hui Zhang#, Yanhua Hou, Menghuan Li*, Zhong Luo*. Progress toward safe tumor diagnosis and therapy via degradable inorganic nanomaterials constructed with metabolically safe elements. ACS Applied Nano Materials 2020, 3: 1028-1042.
71. Ke Li, Menghuan Li, Zhong Luo*, Yulan Mao, Yonglin Yu, Ye He, Jun Zhou, Yang Fei, Yuxia Pei, Kaiyong Cai*. Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel. Biochemical and Biophysical Research Communications 2020, 526: 321-327.
72. Jun Zhou#, Chencheng Xue, Yanhua Hou, Yan Hu, Qiufang Chen, Yanan Li, Ke Li, Guanbin Song, Menghuan Li*, Kaiyong Cai*, Zhong Luo*. Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors. Biomaterials 2019, 197: 129-145.
73. Soo Zeng Fiona Phua#, Chencheng Xue#, Wei Qi Lim, Guangbao Yang, Hongzhong Chen, Yuanyuan Zhang, Chintya Fransisca Wijaya, Zhong Luo*, Yanli Zhao*. Light-responsive prodrug-based supramolecular nanosystems for site-specific combination therapy of cancer. Chemistry of Materials 2019, 31: 3349-3358.
74. Menghuan Li, Zhong Luo*, Zhihong Peng, Kaiyong Cai*. Cascade-amplification of therapeutic efficacy: An emerging opportunity in cancer treatment. WIREs Nanomedicine and Nanobiotechnology 2019, 11: e1555.
75. Maowen Chen, Yan Hu*, Yanhua Hou, Menghuan Li, Maohua Chen, Caiyun Mu, Bailong Tao, We Zhui, Zhong Luo*, Kaiyong Cai*. Differentiation regulation of mesenchymal stem cells via autophagy induced by structurally-different silica based nanobiomaterials. Journal of Materials Chemistry B 2019, 7: 2657-2666.
76. Lu Lu, Xinkun Shen, Bailong Tao, Chuanchuan Lin, Ke Li, Zhong Luo*, Kaiyong Cai*. The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas. Journal of Materials Chemistry B 2019, 7: 2054-2062.
77. Youbo Zhao#, Wei Li#, Menghuan Li*, Yan Hu, Hui Zhang, Guanbin Song, Li Yang, Kaiyong Cai, Zhong Luo*. Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma. Experimental Cell Research 2019, 384: 111591.
78. Jun Zhou, Menghuan Li, Yanhua Hou, Zhong Luo*, Qiufang Chen, Hexu Cao, Runlan Huo, Chencheng Xue, Linawati Sutrisno, Lan Hao, Yang Cao, Haitao Ran, Lu Lu, Ke Li, Kaiyong Cai*. Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy. ACS Nano 2018, 12: 2858- 2872.
79. Menghuan Li, Zhong Luo*, Yanli Zhao*. Recent advancements in 2D nanomaterials for cancer therapy. Science China-Chemistry 2018, 61: 1214-1226.
80. Yuxia Pei#, Menghuan Li#, Zhong Luo*, Yanhua Hou, Guangyu Chu, Liangliang Dai, Ke Li, Yuxin Xing, Bailong Tao, Yonglin Yu, Chencheng Xue, Ye He, Yan Hu*, Kaiyong Cai*. An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy. Nanoscale 2018, 10: 11418-11429.
81. Menghuan Li, Zhong Luo*, and Yanli Zhao*. Self-assembled hybrid nanostructures: versatile multifunctional nanoplatforms for cancer diagnosis and therapy. Chemistry of Materials 2018, 30: 25-153.
82. Jun Zhou#, Menghuan Li#, Wei Qi Lim#, Zhong Luo*, Soo Zeng Fiona Phua, Runlan Huo, Liqi Li, Ke Li, Liangliang Dai, Junjie Liu, Kaiyong Cai, Yanli Zhao*. Transferrin-conjugated hollow nanoplatform for redox-controlled and targeted chemotherapy of tumor with reduced inflammatory reactions. Theranostics 2018, 8: 518-532.
83. Menghuan Li, Zhining Xia, Xinkun Shen, Zhong Luo*, Kaiyong Cai*. Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma. Materials Horizons 2017, 4: 977-996.
84. Ling Huang#, Zhong Luo#, Yan Hu*, Xinkun Shen, Menghuan Li, Liqi Li, Yuan Zhang, Weihu Yang, Peng Liu and Kaiyong Cai*. Enhancement of local bone remodeling in osteoporotic rabbits by biomimic multilayered structures on Ti6Al4V implants. Journal of Biomedical Materials Research Part A 2016, 104:1437-1451.
85. Menghuan Li, Zhong Luo*, Yanli Zhao*. Hybrid nanoparticles as drug carriers for controlled chemotherapy of cancer. Chemical Record 2016, 16: 1833-1851.
86. Zhong Luo#, Yan Hu#, Renlong Xin, Beilu Zhang, Jinghua Li, Xingwei Ding, Yanhua Hou, Li Yang, Kaiyong Cai*. Surface functionalized mesoporous silica nanoparticles with natural proteins for reduced immunotoxicity. Journal of Biomedical Materials Research Part A 2014, 102: 3781-3794.
87. Zhong Luo, Yan Hu*, Kaiyong Cai, Xingwei Ding, Quan Zhang, Menghuan Li, Xing Ma, Beilu Zhang, Yongfei Zeng, Peizhou Li, Jinghua Li, Junjie Liu, Yanli Zhao*. Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. Biomaterials 2014, 35: 7951-7962.
88. Zhong Luo, Xingwei Ding, Yan Hu, Shaojue Wu, Yang Xiang, Yongfei Zeng, Beilu Zhang, Hong Yan, Huacheng Zhang, Liangliang Zhu, Junjie Liu, Jinghua Li, Kaiyong Cai*, Yanli Zhao*. Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. ACS Nano 2013, 7:10271-10284.
89. Zhong Luo, Kaiyong Cai*, Yan Hu, Beilu Zhang, Dawei Xu. Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity. Advanced Healthcare Materials 2012, 1:321-325.
90. Zhong Luo, Kaiyong Cai*, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Weihu Yang, Peng Liu. Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Advanced Materials 2012, 24:431-435.
91. Zhong Luo, Kaiyong Cai*, Yan Hu, Li Zhao, Peng Liu, Lin Duan, Weihu Yang. Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery. Angew Chem Int Ed 2011, 50: 640-643.
92. Zhong Luo, Kaiyong Cai*, Beilu Zhang, Duan Lin, Aiping Liu, Gong Duan. Application of mesoporous silica nanoreservoir in smart drug controlled release systems. Progress in Chemistry 2011, 23: 2326-2338.
93. Kaiyong Cai*, Zhong Luo, Yan Hu, Xiuyong Chen, Li Yang, Linhong Deng. Magnetically triggered reversible controlled drug delivery from microfabricated polymeric multireservoir devices. Advanced Materials 2009; 21(40): 4045-4049.
