2000 - 2004 BS, Sichuan University
2004 - 2010 PhD, Shanghai Institutes for Biological Sciences
2011 - 2014 Postdoc, University of Southern California, US
2014 - now PI, Professor, Chongqing University
Research interests
Aging is a big risk factor for many chronic diseases, which are named "Aging-related diseases". Mechanisms that retard aging process generally prevent the onset of aging-related diseases. Our lab is interested in deciphering the metabolic mechanisms of aging and longevity, seeking to identify novel metabolites that regulating animal lifespan and uncover the underlying molecular mechanisms.
Major achievement
Selected publications
1. Zhou L, He B, Deng J, Pang S*, Tang H*. Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress. PLoS Genet. 15(4): e1008122. (2019) (* correspondence)
2. Tang H, Pang S. Proline catabolism modulates innate immunity in C. elegans. Cell Reports 17(11): 2837-2844. (2016)
3. Pang S, Lynn D, Lo J, Curran SP. SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation. Nature Communications 5:5048. (2014).
4. Pang S, Curran SP. Adaptive capacity to bacterial diet modulates aging in C. elegans. Cell Metabolism 19(2): 221-231. (2014). (Previewed as a leading edge finding in Cell Metabolism 19(2): 177-178, 2014)
5. Pang S, Curran SP. Longevity and the long arm of epigenetics: acquired parental marks influence lifespan across several generations. Bioessays 34(8): 652-654. (2012)
6. Zhang L, Pang S, Deng B, Qian L, Chen J, Zou J, Zheng J, Yang L, Zhang C, Chen X, Liu Z, Le Y. High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. Int J Biochem Cell Biol 44: 629-638. (2012)
7. Pang S, Tang H, Zhuo S, Zang YQ and Le Y. Regulation of fasting fuel metabolism by Toll-like receptor 4. Diabetes 59: 3041-3048. (2010)
8. Tang H, Pang S, Wang M, Xiao X, Rong Y, Wang H, Zang YQ. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice. J Immunol 185: 2563-2569. (2010)
9. Wang O, Cai K, Pang S, Wang T, Qi D, Zhu Q, Ni Z, Le Y. Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells. Endocrinology.149:672-680. (2008)
10. Pang S, Le Y. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol 3:29-34. (2006)
