Chuan Huang, Ph.D. Professor.PI.
I graduated from University of Science and Technology of China, and obtained Ph.D. degree in March 2016. Then I started poctdoc training in June 2016. I got granted by 100 talent program in October 2018.
Research interests
RESEARCH FOCUS 1: Identify circular RNA export mechanisms
RESEARCH FOCUS 2: Identify circular RNA decay pathway
RESEARCH FOCUS 3: Identify various ncRNAs and their biological functions
Courses
molecular biology, biochemistry, genetics and cell biology.
Academic position
Nature Communications reviewer, Genes & development reviewer, RNA Biology reviewer
Major achievement
(#corresponding author/通讯作者)
(1). Song Z, Lin J, Su R, Ji Y, Jia R, Li S, Shan G, Huang C#. eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells. Nucleic Acids Research 2022; 50:11529–11549. (F1000prime Recommendation)
(2). Chen L, Wang Y, Lin J, Song Z, Wang Q, Zhao W, Wang Y, Xiu X, Deng Y, Li X, Li Q, Wang X, Li J, Liu X, Liu K, Zhou J, Li K, Liu Y, Liao S, Deng Q, Xu C, Sun Q, Wu S, Zhang K, Guan M, Zhou T, Sun F, Cai X, Huang C#, Shan G#. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs. Nature Communications 2022; 13:5769.
(3). Jia R, Lin J, You J, Li S, Shan G, Huang C#. The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes. Nucleic Acids Research 2022; 50:9175-9189.
(4). Chen X, Zhou M, Yant L, Huang C#. Circular RNA in disease: basic properties and biomedical relevance. Wiley Interdisciplinary Reviews-RNA 2022; 13:e1723.
(5). Chen L, Huang C#, Shan G#. Circular RNAs in physiology and non-immunological diseases. Trends in Biochemical Sciences 2022; 47:250-264.
(6). You J, Song Z, Lin J, Jia R, Xia F, Li Z, Huang C#. RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus. Cell Discovery 2021; 7:79.
(7). Jia R, Song Z, Lin J, Li Z, Shan G, Huang C#. Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Nucleic Acids Research 2021; 49:6296-6314. (Research Highlights in Current Opinion in Insect Science)
(8). Song Z, Jia R, Tang M, Xia F, Xu H, Li Z, Huang C#. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Science China-Life Sciences 2021; 64:784-794.
(9). Song Z, Lin J, Li Z, Huang C#. The nuclear functions of long noncoding RNAs come into focus. Noncoding RNA Research 2021; 6:70-79.
(10). Zhou M, Xiao MS, Li Z, Huang C#. New progresses of circular RNA biology: from nuclear export to degradation. RNA Biology 2021; 18:1365-1373.
(11). Jia R, Xiao M, Li Z, Shan G, Huang C#. Defining an evolutionarily conserved role of GW182 in circular RNA degradation. Cell Discovery 2019; 5:49.
(12). Li Z, Kearse GM, Huang C#. The nuclear export of circular RNAs is primarily defined by their length. RNA Biology 2019; 16:1-4.
(13). Huang C, Liang D, Tatomer DC, Wilusz JE. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes & Development 2018; 32:639-644. (F1000prime Recommendation; Selected for an Outlook in Genes & Development; Perspectives and Commentary in Science: The long and short of RNA export. Science Vol. 360, No. 6393)
(14). Huang C, Wang X, Liu X, Cao S, Shan G. RNAi pathway participates in chromosome segregation in mammalian cells. Cell Discovery 2015; 1:15029. (Featured Article in Cell Discovery)
(15). Chen L, Huang C, Wang X, Shan G. Circular RNAs in Eukaryotic Cells. Current Genomics 2015; 16:312-318.
(16). Huang C, Shan G. What happens at or after transcription: Insights into circRNA biogenesis and function. Transcription 2015; 6:61-64.
(17). Li Z*, Huang C*, Bao C*, Chen L, Lin M, Wang X, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nature Structural & Molecular Biology 2015; 22:256-64. (*co-first author; Research Highlights in Nature Reviews Molecular Cell Biology: Circular RNAs promote transcription, 2015, 16(4); Editors’ Choice in Science: Circular RNA transcriptional circuits, 2015, 347(6228):1327; Featured Article & Most Cited Paper in Nature Structural & Molecular Biology)
(18). Dai L, Huang C, Chen L, Shan G, Li ZY. Altered expression of microRNAs in the response to ER stress. Science Bulletin 2015; 60:202-209.
Awards
2018 Kuashal Award (nominated)
2016 Outstanding Graduate Student Award of University of Science and Technology of China
2015 Chinese Academy of Science Award (Zhu Li Yuehua National Award)
Outstanding Paper Award of University of Science and Technology of China
Outstanding Presentation Award of University of Science and Technology of China
2013 University of Science and Technology of China In-House Symposium Outstanding Poster Prize
2011 - 2016 Graduate Fellowships of Science and Technology of China
Postgraduate training
Training Ph.D. students who are interested in molecular biology, biochemistry, genetics and cell biology.
Contact information
School of Life Sciences, Chongqing University, Chongqing, China
Email: chuanhuang@cqu.edu.cn
